Incidence of infections in adult patients with central venous catheter: A systematic review
DOI:
https://doi.org/10.62486/agsalud202384Keywords:
Central Venous Catheters, Incidence, Catheter-Related Infections, Intensive Care Units, AdultAbstract
Background: Central venous catheter (CVC)-associated infections are infections that develop due to the insertion of a catheter into a central or peripheral vein. These infections represent an important cause of morbidity and mortality in hospitalized patients. The implementation of prevention packages, including measures such as hand hygiene and the application of sterile barriers, has been shown to reduce the incidence of these infections. Other risk factors include the length of the catheter, the patient's comorbidities, and compliance with prevention measures. Material and methods: The study design was that of a systematic review of the literature. Selected articles from the specific search that met the inclusion criteria were analyzed, except for articles that met some exclusion criteria. Results: Average percentage of infection every 100 days = 0.64%. Median percentage of infection every 100 days= 0.42%. Conclusion: In conclusion, it is important to implement effective prevention measures in the insertion and management of central venous catheters. These measures include hand hygiene, proper preparation of the insertion site, education and training of medical personnel, and the use of protective barriers. By consistently applying these measures, the incidence of CVC-associated infections can be significantly reduced and patient safety and care improved.
References
Marschall J, Mermel LA, Fakih M, Hadaway L, Kallen A, O'Grady NP, Pettis AM, Rupp ME, Sandora T, Maragakis LL, Yokoe DS. Strategies to prevent central line-associated bloodstream infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014 Sep;35 Suppl 2:S89-107. PMID: 25376071.
Pronovost P, Needham D, Berenholtz S, Sinopoli D, Chu H, Cosgrove S, Sexton B, Hyzy R, Welsh R, Roth G, Bander J, Kepros J, Goeschel C. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med. 2006 Dec 28;355(26):2725-32. doi: 10.1056/NEJMoa061115. Erratum in: N Engl J Med. 2007 Jun 21;356(25):2660. PMID: 17192537.
Berenholtz SM, Pronovost PJ, Lipsett PA, Hobson D, Earsing K, Farley JE, Milanovich S, Garrett-Mayer E, Winters BD, Rubin HR, Dorman T, Perl TM. Eliminating catheter-related bloodstream infections in the intensive care unit. Crit Care Med. 2004 Oct;32(10):2014-20. doi: 10.1097/01.ccm.0000142399.70913.2f. PMID: 15483409.
Safdar N, Maki DG. The pathogenesis of catheter-related bloodstream infection with noncuffed short-term central venous catheters. Intensive Care Med. 2004 Jan;30(1):62-7. doi: 10.1007/s00134-003-2045-z. Epub 2003 Nov 26. PMID: 14647886.
Raad I, Chatzinikolaou I, Chaiban G, Hanna H, Hachem R, Dvorak T, Cook G, Costerton W. In vitro and ex vivo activities of minocycline and EDTA against microorganisms embedded in biofilm on catheter surfaces. Antimicrob Agents Chemother. 2003 Nov;47(11):3580-5. doi: 10.1128/AAC.47.11.3580-3585.2003. PMID: 14576121; PMCID: PMC253809.
Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, Raad II, Rijnders BJ, Sherertz RJ, Warren DK. Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2009 Jul 1;49(1):1-45. doi: 10.1086/599376. Erratum in: Clin Infect Dis. 2010 Apr 1;50(7):1079. Dosage error in article text. Erratum in: Clin Infect Dis. 2010 Feb 1;50(3):457. PMID: 19489710; PMCID: PMC4039170.
O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, Heard SO, Lipsett PA, Masur H, Mermel LA, Pearson ML, Raad II, Randolph AG, Rupp ME, Saint S; Healthcare Infection Control Practices Advisory Committee (HICPAC). Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis. 2011 May;52(9):e162-93. doi: 10.1093/cid/cir257. Epub 2011 Apr 1. PMID: 21460264; PMCID: PMC3106269.
Bell T, O'Grady NP. Prevention of Central Line-Associated Bloodstream Infections. Infect Dis Clin North Am. 2017 Sep;31(3):551-559. doi: 10.1016/j.idc.2017.05.007. Epub 2017 Jul 5. PMID: 28687213; PMCID: PMC5666696.
Zingg W, Sax H, Inan C, Cartier V, Diby M, Clergue F, Pittet D, Walder B. Hospital-wide surveillance of catheter-related bloodstream infection: from the expected to the unexpected. J Hosp Infect. 2009 Sep;73(1):41-6. doi: 10.1016/j.jhin.2009.05.015. Epub 2009 Jul 30. PMID: 19646788.
Baier C, Linke L, Eder M, Schwab F, Chaberny IF, Vonberg RP, Ebadi E. Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients. PLoS One. 2020 Jan 24;15(1):e0227772. doi: 10.1371/journal.pone.0227772. PMID: 31978169; PMCID: PMC6980604.
Takeshita J, Tachibana K, Nakajima Y, Shime N. Incidence of catheter-related bloodstream infections following ultrasound-guided central venous catheterization: a systematic review and meta-analysis. BMC Infect Dis. 2022 Oct 4;22(1):772. doi: 10.1186/s12879-022-07760-1. PMID: 36195853; PMCID: PMC9533546.
Loveday HP, Wilson JA, Pratt RJ, Golsorkhi M, Tingle A, Bak A, Browne J, Prieto J, Wilcox M, UK Department of Health. epic3: national evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England. J Hosp Infect. 2014 Jan;86 Suppl 1:S1-70. doi: 10.1016/S0195-6701(13)60012-2. PMID: 24330862; PMCID: PMC7114876.
Zimlichman E, Henderson D, Tamir O, Franz C, Song P, Yamin CK, Keohane C, Denham CR, Bates DW. Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system. JAMA Intern Med. 2013 Dec 9-23;173(22):2039-46. doi: 10.1001/jamainternmed.2013.9763. PMID: 23999949.
Hammarskjöld F, Berg S, Hanberger H, Taxbro K, Malmvall BE. Sustained low incidence of central venous catheter-related infections over six years in a Swedish hospital with an active central venous catheter team. Am J Infect Control. 2014 Feb;42(2):122-8. doi: 10.1016/j.ajic.2013.09.023. PMID: 24485369.
Gudiol C, Arnan M, Aguilar-Guisado M, Royo-Cebrecos C, Sánchez-Ortega I, Montero I, Martín-Gandul C, Laporte-Amargós J, Albasanz-Puig A, Nicolae S, Perayre M, Berbel D, Tebe C, Riera J, Sureda A, Cisneros JM, Carratalà J. A Randomized, Double-Blind, Placebo-Controlled Trial (TAURCAT Study) of Citrate Lock Solution for Prevention of Endoluminal Central Venous Catheter Infection in Neutropenic Hematological Patients. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01521-19. doi: 10.1128/AAC.01521-19. PMID: 31712211; PMCID: PMC6985755.
Kang J, Chen W, Sun W, Ge R, Li H, Ma E, Su Q, Cheng F, Hong J, Zhang Y, Lei C, Wang X, Jin A, Liu W. Peripherally inserted central catheter-related complications in cancer patients: a prospective study of over 50,000 catheter days. J Vasc Access. 2017 Mar 21;18(2):153-157. doi: 10.5301/jva.5000670. Epub 2017 Feb 8. PMID: 28218366.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Régis Silveira Borges, Marcelo Estrin (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
