Observational retrospective study on amylase dosage and severity of pancreatic fistula
DOI:
https://doi.org/10.62486/agsalud202385Keywords:
pancreatic fistula, pancreatic fistula AND amylase, Pancreatic Fistula, abdominal drainage, Predictive AND factors AND "pancreatic fistula, AND severityAbstract
Background: Pancreatic fistula is a complication in pancreatic surgery. It is important to predict its occurrence to guide postoperative management. There are few studies on the correlation between amylase levels in the drainage fluid and the risk of pancreatic fistula. The aim of the study was to determine whether the amylase level on postoperative day 3 can predict the severity of pancreatic fistula. Material and methods: A retrospective study was performed in patients who underwent duodenopancreatectomy to evaluate the relationship between the amylase value in intra-abdominal drainage on postoperative day 3 and the severity of pancreatic fistula. The relationship between surgical and conventional biochemical results was analyzed. Student's t-test was used for statistical analysis with a value of p<0.05 considered significant. Results: No significant differences or statistically significant correlations were found between the groups evaluated. Conclusion: Isolated measurement of amylase in draining fluid in the early postoperative period is not sufficient but is very useful in predicting the occurrence of FP associated with complications and prolonged hospital stay. Further research is required to reduce its incidence.
References
Bassi C, Dervenis C, Butturini G, et al. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005;138(1):8-13. doi:10.1016/j.surg.2005.05.001
Dugalic VD, Knezevic DM, Obradovic VN, et al. Drenar el valor de la amilasa como predictor temprano de fístula pancreática después de la duodenopancreatectomía cefálica. Mundo J Gastroenterol. 2014;20(26):8691-8699. doi:10.3748/wjg.v20.i26.8691
Crippa S, Salvia R, Falconi M, Butturini G, Landoni L, Bassi C. Anastomotic leakage in pancreatic surgery. HPB (Oxford). 2007;9(1):8-15. doi:10.1080/13651820600641357
Pratt WB, Maithel SK, Vanounou T, Huang ZS, Callery MP, Vollmer CM Jr. Validación clínica y económica del esquema de clasificación del Grupo Internacional de Estudio de la Fístula Pancreática (ISGPF). Ann Surg. 2007;245(3):443-451. doi:10.1097/01.sla.0000251708.70219.d2
Moskovic DJ, Hodges SE, Wu MF, Brunicardi FC, Hilsenbeck SG, Fisher WE. Drain data to predict clinically relevant pancreatic fistula. HPB (Oxford). 2010;12(7):472-481. doi:10.1111/j.1477-2574.2010.00212.x
Gebauer F, Kloth K, Tachezy M, et al. Opciones y limitaciones en la aplicación de la clasificación de la fístula por el Grupo Internacional de Estudio de la Fístula Pancreática. Ann Surg. 2012;256(1):130-138. doi:10.1097/SLA.0b013e31824f24e4
Molinari E, Bassi C, Salvia R, et al. Amylase value in drains after pancreatic resection as predictive factor of postoperative pancreatic fistula: results of a prospective study in 137 patients. Ann Surg. 2007;246(2):281-287. doi:10.1097/SLA.0b013e3180caa42f
Kawai M, Kondo S, Yamaue H, et al. Predictive risk factors for clinically relevant pancreatic fistula analyzed in 1,239 patients with pancreaticoduodenectomy: multicenter data collection as a project study of pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci. 2011;18(4):601-608. doi:10.1007/s00534-011-0373-x
Fuks D, Piessen G, Huet E, et al. Life-threatening postoperative pancreatic fistula (grade C) after pancreaticoduodenectomy: incidence, prognosis, and risk factors. Am J Surg. 2009;197(6):702-709. doi:10.1016/j.amjsurg.2008.03.004
Kawai M, Tani M, Hirono S, Ina S, Miyazawa M, Yamaue H. How do we predict the clinically relevant pancreatic fistula after pancreaticoduodenectomy?--an analysis in 244 consecutive patients. World J Surg. 2009;33(12):2670-2678. doi:10.1007/s00268-009-0220-2
Callery MP, Pratt WB, Kent TS, Chaikof EL, Vollmer CM Jr. A prospectively validated clinical risk score accurately predicts pancreatic fistula after pancreatoduodenectomy. J Am Coll Surg. 2013;216(1):1-14. doi:10.1016/j.jamcollsurg.2012.09.002
Schmidt CM, Choi J, Powell ES, et al. Fístula pancreática después de la pancreaticoduodenectomía: predictores clínicos y resultados del paciente. HPB Surg. 2009;2009:404520. doi:10.1155/2009/404520
Reid-Lombardo KM, Farnell MB, Crippa S, et al. Pancreatic anastomotic leakage after pancreaticoduodenectomy in 1,507 patients: a report from the Pancreatic Anastomotic Leak Study Group. J Gastrointest Surg. 2007;11(11):1451-1459. doi:10.1007/s11605-007-0270-4
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Silvina Guadalupe Nuss, Lucio Uranga (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
